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What time of day is TSH highest? Thirty-five years ago, fluctuating TSH levels were demonstrated and found to be at their highest in the middle of the night. Current research suggests that TSH serum levels peak at between 2 am and 4 am and decrease to their lowest levels at between 4 pm and 8 pm.
Does levothyroxine have t3 and t4? The thyroid gland produces the thyroid hormone triiodothyronine (T3) and thyroxine (T4). T3 is more potent that T4, which means that one mg of T3 has a greater effect on the body than one mg of T4. Levothyroxine (Synthroid) is a synthetic version of T4, and liothyronine (Cytomel) is a synthetic version of T3.

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